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Title: Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess.
Author: Samino, Sara
Vinaixa Crevillent, Maria
Díaz, Marta
Beltran, Antoni
Rodríguez, Miguel A.
Mallol, Roger
Heras, Mercedes
Cabré, Anna
García, Lorena
Canela, Nuria
Zegher, Francis de
Correig Blanchar, Xavier
Ibáñez Toda, Lourdes
Yanes, Oscar
Keywords: Adolescents
Hormones sexuals
Lipoproteïnes de la sang
Sex hormones
Blood lipoproteins
Issue Date: 23-Jun-2015
Publisher: Nature Publishing Group
Abstract: Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2015, vol. 5, p. 11496
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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