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http://hdl.handle.net/2445/105867
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DC Field | Value | Language |
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dc.contributor.author | Samino Gené, Sara | - |
dc.contributor.author | Vinaixa Crevillent, Maria | - |
dc.contributor.author | Díaz, Marta | - |
dc.contributor.author | Beltran, Antoni | - |
dc.contributor.author | Rodríguez, Miguel Angel | - |
dc.contributor.author | Mallol, Roger | - |
dc.contributor.author | Heras, Mercedes | - |
dc.contributor.author | Cabré Llobet, Anna | - |
dc.contributor.author | García, Lorena | - |
dc.contributor.author | Canela i Canela, Núria | - |
dc.contributor.author | Zegher, Francis de | - |
dc.contributor.author | Correig Blanchar, Xavier | - |
dc.contributor.author | Ibáñez Toda, Lourdes | - |
dc.contributor.author | Yanes, Oscar | - |
dc.date.accessioned | 2017-01-19T16:47:27Z | - |
dc.date.available | 2017-01-19T16:47:27Z | - |
dc.date.issued | 2015-06-23 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/105867 | - |
dc.description.abstract | Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep11496 | - |
dc.relation.ispartof | Scientific Reports, 2015, vol. 5, p. 11496 | - |
dc.relation.uri | https://doi.org/10.1038/srep11496 | - |
dc.rights | cc-by-nc-nd (c) Samino, Sara et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Adolescents | - |
dc.subject.classification | Andrògens | - |
dc.subject.classification | Hormones sexuals | - |
dc.subject.classification | Lipoproteïnes de la sang | - |
dc.subject.other | Teenagers | - |
dc.subject.other | Androgens | - |
dc.subject.other | Sex hormones | - |
dc.subject.other | Blood lipoproteins | - |
dc.title | Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 657365 | - |
dc.date.updated | 2017-01-19T16:47:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26099471 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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657365.pdf | 935.46 kB | Adobe PDF | View/Open |
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