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http://hdl.handle.net/2445/105882Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Pérez Tomás, Ricardo E. | - |
| dc.contributor.author | Mayol, X. | - |
| dc.contributor.author | Culleré i Luengo, F. Xavier | - |
| dc.contributor.author | Díaz Ruiz, Carmen | - |
| dc.contributor.author | Domingo i Feliudabaló, Jordi | - |
| dc.date.accessioned | 2017-01-20T08:24:54Z | - |
| dc.date.available | 2017-01-20T08:24:54Z | - |
| dc.date.issued | 1992-07 | - |
| dc.identifier.issn | 0213-3911 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/105882 | - |
| dc.description.abstract | Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo. | - |
| dc.format.extent | 6 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Universidad de Murcia | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://digitum.um.es/xmlui/handle/10201/18324 | - |
| dc.relation.ispartof | Histology and Histopathology, 1992, vol. 7, num. 3, p. 457-462 | - |
| dc.rights | cc-by-nc-nd (c) Universidad de Murcia, 1992 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
| dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
| dc.subject.classification | Tumors | - |
| dc.subject.classification | Cèl·lules hepàtiques | - |
| dc.subject.classification | Rates (Animals de laboratori) | - |
| dc.subject.classification | Factors de creixement | - |
| dc.subject.classification | Càncer de fetge | - |
| dc.subject.classification | Histopatologia veterinària | - |
| dc.subject.other | Tumors | - |
| dc.subject.other | Liver cells | - |
| dc.subject.other | Rats as laboratory animals | - |
| dc.subject.other | Growth factors | - |
| dc.subject.other | Liver cancer | - |
| dc.subject.other | Veterinary histopathology | - |
| dc.title | Transforming growth factor -α expression in rat experimental hepatocarcinogenesis | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 073060 | - |
| dc.date.updated | 2017-01-20T08:24:54Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 073060.pdf | 3.5 MB | Adobe PDF | View/Open |
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