Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/106264
Title: Disruption of brain white matter microstructure in females with anorexia nervosa
Author: Via, Esther
Zalesky, Andrew
Sánchez Zaplana, Isabel
Forcano, Laura
Harrison, Ben J.
Pujol, Jesús
Fernández Aranda, Fernando
Menchón Magriñá, José Manuel
Soriano Mas, Carles
Cardoner, N. (Narcís)
Fornito, Alex
Keywords: Anorèxia nerviosa
Dones
Circuit neuronal
Cervell
Anorexia nervosa
Women
Neural circuitry
Brain
Issue Date: 1-Nov-2014
Publisher: Canadian Medical Association
Abstract: Background: The etiology of anorexia nervosa is still unknown. Multiple and distributed brain regions have been implicated in its pathophysiology, implying a dysfunction of connected neural circuits. Despite these findings, the role of white matter in anorexia nervosa has been rarely assessed. In this study, we used diffusion tensor imaging (DTI) to characterize alterations of white matter microstructure in a clinically homogeneous sample of patients with anorexia nervosa. Methods: Women with anorexia nervosa (restricting subtype) and healthy controls underwent brain DTI. We used tract-based spatial statistics to compare fractional anisotropy (FA) and mean diffusivity (MD) maps between the groups. Furthermore, axial (AD) and radial diffusivity (RD) measures were extracted from regions showing group differences in either FA or MD. Results: We enrolled 19 women with anorexia nervosa and 19 healthy controls in our study. Patients with anorexia nervosa showed significant FA decreases in the parietal part of the left superior longitudinal fasciculus (SLF; pFWE < 0.05), with increased MD and RD but no differences in AD. Patients with anorexia nervosa also showed significantly increased MD in the fornix (pFWE < 0.05), accompanied by decreased FA and increased RD and AD. Limitations: Limitations include our modest sample size and cross-sectional design. Conclusion: Our findings support the presence of white matter pathology in patients with anorexia nervosa. Alterations in the SLF and fornix might be relevant to key symptoms of anorexia nervosa, such as body image distortion or impairments in body-energy-balance and reward processes. The differences found in both areas replicate those found in previous DTI studies and support a role for white matter pathology of specific neural circuits in individuals with anorexia nervosa.
Note: Reproducció del document publicat a: https://doi.org/10.1503/jpn.130135
It is part of: Journal of Psychiatry & Neuroscience, 2014, vol. 39, num. 6, p. 367-375
Related resource: https://doi.org/10.1503/jpn.130135
URI: http://hdl.handle.net/2445/106264
ISSN: 1180-4882
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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