Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/106491
Title: Opposite cannabis-cognition associations in psychotic patients depending on family history
Author: González Pinto, Ana
González Ortega, Itxaso
Alberich, Susana
Ruiz de Azúa, Sonia
Bernardo Arroyo, Miquel
Bioque Alcázar, Miquel
Cabrera, Bibiana
Corripio, Iluminada
Arango, Celso
Lobo, Antonio
Sánchez-Torres, Ana M.
Cuesta, Manuel J.
PEPS Group
Keywords: Cànnabis
Psicosi
Malalties hereditàries
Memòria
Cognició
Neuropsicologia clínica
Cannabis
Psychoses
Genetic diseases
Memory
Cognition
Clinical neuropsychology
Issue Date: 11-Aug-2016
Publisher: Public Library of Science (PLoS)
Abstract: The objective of this study is to investigate cognitive performance in a first-episode psycho- sis sample, when stratifying the interaction by cannabis use and familial or non-familial psy- chosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family his- tory of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no fam- ily history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0160949
It is part of: PLoS One, 2016, vol. 11, num. 8, p. e0160949
Related resource: https://doi.org/10.1371/journal.pone.0160949
URI: http://hdl.handle.net/2445/106491
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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