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Title: Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited.
Author: Rodríguez Allué, Manuel José
Mahy Gehenne, Josette Nicole
Keywords: Esclerosi lateral amiotròfica
Neurones motores
Malalties neurodegeneratives
Amyotrophic lateral sclerosis
Motor neurons
Neurodegenerative diseases
Issue Date: 1-Jun-2016
Publisher: Bentham Science Publishers
Abstract: Research into the pathogenesis of amyotrophic lateral sclerosis (ALS) has obtainedd notable gene discoveries, although, to date, only progress with regard to treatment has been very modest. Currently ALS is considered a multifactorial disease that presents diverse clinical presentations, ranging from a monogenic inherited disease to an autoimmune pathology, and develops with misfolded protein aggregation and neuroinflammation. An important factor related to ALS pathogenesis is the microglial activation associated with degenerative motor neurons. This activation leads to changes in the expression of a wide range of genes related to phagocytosis and inflammation, and to profound modifications in the dynamic interactions between neurons and glial cells. Overactivation and deregulation of microglial activity causes deleterious effects and leads to neuronal death. However, the involvement of microglia in non-inflammatory functions challenges our concept of neuroinflammation and opens up new possibilities for the study of the pathophysiological mechanisms of ALS. In this review we summarize the current knowledge on the adaptive interactions between neurons and microglia in ALS. We also discuss the hypothesis that controlling the extent of microglial activation and neuroinflammation may have clinical and therapeutic benefits for the condition.
Note: Versió postprint del document publicat a:
It is part of: Current Medicinal Chemistry, 2016, vol. 23, num. 42, p. 4753-4772
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ISSN: 0929-8673
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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