Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/106786
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Torres, Berta | - |
dc.contributor.author | Rallón, Norma | - |
dc.contributor.author | Loncá, Montserrat | - |
dc.contributor.author | Díaz Lorca, Maria Alba | - |
dc.contributor.author | Alós i Hernández, Llúcia | - |
dc.contributor.author | Martínez Chamorro, Esteban José | - |
dc.contributor.author | Cruceta, Anna | - |
dc.contributor.author | Arnaiz Gargallo, Juan Alberto | - |
dc.contributor.author | Leal, Lorna | - |
dc.contributor.author | Lucero, Constanza | - |
dc.contributor.author | León García, Agathe | - |
dc.contributor.author | Sánchez, Marcelo | - |
dc.contributor.author | Negredo, Eugènia | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Benito, José M. | - |
dc.contributor.author | García Alcaide, Felipe | - |
dc.date.accessioned | 2017-02-10T11:41:05Z | - |
dc.date.available | 2017-02-10T11:41:05Z | - |
dc.date.issued | 2014-05-02 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | http://hdl.handle.net/2445/106786 | - |
dc.description.abstract | CD4+ count increase has been reported to be different with lopinavir/r (LPV/r) and efavirenz (EFV)-containing regimens. The different effect of these two regimens on other immune function parameters and the relationship with the gain of CD4+ count have not been assessed in a randomized clinical trial. Fifty antiretroviral treatment (cART) naïve HIV-infected individuals were randomized to receive LPV/r or EFV both with tenofovir/emtricitabine for 48 weeks. A substudy of immunological function restoration was performed in 22 patients (LPV/r n=10 and EFV n=12). Activation, thymic function, apoptosis, senescence, exhaustion, Treg cells, interleukin (IL)-7-receptor/IL-7 system, thymic volume, and lymphoid tissue fibrosis were evaluated at baseline and at week 48. Both groups experienced a CD4+ count increase that was higher in the EFV group (ΔCD4+ 88 vs. 315 cells/μl LPV/r vs. EFV, respectively, p<0.001). Despite this difference in CD4+ gain, the change in other immune function parameters was similar in both treatment groups. Most of parameters evaluated tended to normalize after 48 weeks of cART. A significant decrease in levels of activation, senescence, exhaustion, and apoptosis on CD4+ and CD8+ T cells (p<0.001 for all) and a significant increase in markers of thymic function, IL-7 receptor, and in the levels of central memory CD4+ T cells and naive subsets of CD8+ T cells (p<0.001 for all) with respect to baseline values were observed without any difference between groups. These data indicate that the differences in CD4+ gain with different cART regimens are not immunologically meaningful and might explain the similar clinical efficacy of these regimens. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Mary Ann Liebert | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1089/aid.2013.0185 | - |
dc.relation.ispartof | Aids Research and Human Retroviruses, 2014, vol. 30, num. 5, p. 425-433 | - |
dc.relation.uri | https://doi.org/10.1089/aid.2013.0185 | - |
dc.rights | (c) Mary Ann Liebert, 2014 | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Sistema immunològic | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Immune system | - |
dc.subject.other | Antiretroviral agents | - |
dc.title | Immunological function restoration with Lopinavir/ritonavir vs Efavirenz containing regimens in HIV infected patients: a randomized clinical trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 635577 | - |
dc.date.updated | 2017-02-10T11:41:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24380397 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
635577.pdf | 463.91 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.