Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/106922
Title: In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes
Author: Cuzmar, Erika
Perez, Roman A.
Manzanares Céspedes, María Cristina
Ginebra, Maria Pau
Franch, Jordi
Keywords: Ossificació
Teixit ossi
Creixement dels ossos
Col·lagen
Calci
Biomimètica
Ossification
Bone
Bones growth
Collagen
Calcium
Biomimetics
Issue Date: 1-Jul-2015
Publisher: Public Library of Science (PLoS)
Abstract: The Osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in vivo model, and compared with an injectable calcium phosphate cement with the same composition. The materials were implanted into a 5 mm defect in the femur condyle of rabbits, and bone formation was assessed after 1 and 3 months. The histological analysis revealed that the cements presented cellular activity only in the margins of the material, whereas each one of the individual microspheres was covered with osteogenic cells. Consequently, bone ingrowth was enhanced by the microspheres, with a tenfold increase compared to the cement, which was associated to the higher accessibility for the cells provided by the macroporous network between the microspheres, and the larger surface area available for osteoconduction. No significant differences were found in terms of bone formation associated with the presence of collagen in the materials, although a more extensive erosion of the collagen-containing microspheres was observed.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131188
It is part of: PLoS One, 2015, vol. 10, num. 7, p. e0131188
Related resource: https://doi.org/10.1371/journal.pone.0131188
URI: http://hdl.handle.net/2445/106922
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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