Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/107268
Title: Course and determinants of anosognosia in Alzheimer's disease: a 12-month follow-up
Author: Turró-Garriga, O.
Garre Olmo, Josep
Calvó-Perxas, Laia
Reñé Ramírez, Ramon
Gascón-Bayarri, J.
Conde Sala, Josep Lluís
Keywords: Malaltia d'Alzheimer
Mètode longitudinal
Demència
Alzheimer's disease
Longitudinal method
Dementia
Issue Date: Feb-2016
Publisher: IOS Press
Abstract: Anosognosia in Alzheimer's disease (AD) has been associated with greater cognitive impairment and more behavioural and psychological symptoms of dementia (BPSD). This study examines the incidence, persistence, and remission rates of anosognosia over a 12-month period, as well as the related risk factors. This was an observational 12-month prospective study. The longitudinal sample comprised 177 patients with mild or moderate AD, and their respective caregivers. Anosognosia was assessed using the Anosognosia Questionnaire in Dementia, and we also evaluated cognitive status (Mini-Mental State Examination), functional disability (Disability Assessment in Dementia), and the presence of BPSD (Neuropsychiatric Inventory). Multinomial logistic regression was used to determine the variables associated with the incidence, persistence and remission of anosognosia. The prevalence of anosognosia was 39.5% (95% CI = 32.1-47.1) at baseline. At 12 months, incidence was 38.3% (95% CI = 28.6-48.0), persistence was 80.0% (95% CI = 69.9-90.1) and remission was 20.0% (95% CI = 9.9-30.1). The regression model identified lower age, more education, and the presence of delusions as variables associated with incidence, and more education, lower instrumental DAD score, and disinhibition as variables associated with persistence. No variables were associated with remission (n = 14). The presence of anosognosia in AD patients is high. Education and certain neuropsychiatric symptoms may explain a greater and earlier incidence of anosognosia. However, anosognosia also increases with greater cognitive impairment and disease severity
Note: Reproducció del document publicat a: https://doi.org/10.3233/JND-150706
It is part of: Journal of Alzheimer's Disease, 2016, vol. 51, num. 2, p. 357-366
Related resource: https://doi.org/10.3233/JND-150706
URI: http://hdl.handle.net/2445/107268
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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