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Title: The voltage-dependent K+ channels Kv1.3 and Kv1.5 in human cancer
Author: Comes, Núria
Bielanska, Joanna
Vallejo-Gracia, Albert
Serrano-Albarrás, Antonio
Marruecos, Laura
Gómez Fernández, Diana Lucía
Soler, Concepció
Condom, Enric
Ramón y Cajal Agüeras, Santiago
Hernández-Losa, Javier
Ferreres, Joan C.
Felipe, Antonio
Keywords: Càncer
Canals de potassi
Marcadors tumorals
Potassium channels
Tumor markers
Issue Date: 10-Oct-2013
Publisher: Frontiers Media
Abstract: Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes, including immunomodulation, cell volume regulation, apoptosis as well as differentiation. Some Kv channels participate in the proliferation and migration of normal and tumor cells, contributing to metastasis. Altered expression of Kv1.3 and Kv1.5 channels has been found in several types of tumors and cancer cells. In general, while the expression of Kv1.3 apparently exhibits no clear pattern, Kv1.5 is induced in many of the analyzed metastatic tissues. Interestingly, evidence indicates that Kv1.5 channel shows inversed correlation with malignancy in some gliomas and non-Hodgkin's lymphomas. However, Kv1.3 and Kv1.5 are similarly remodeled in some cancers. For instance, expression of Kv1.3 and Kv1.5 correlates with a certain grade of tumorigenicity in muscle sarcomas. Differential remodeling of Kv1.3 and Kv1.5 expression in human cancers may indicate their role in tumor growth and their importance as potential tumor markers. However, despite of this increasing body of information, which considers Kv1.3 and Kv1.5 as emerging tumoral markers, further research must be performed to reach any conclusion. In this review, we summarize what it has been lately documented about Kv1.3 and Kv1.5 channels in human cancer.
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It is part of: Frontiers in Physiology, 2013, vol. 4, num. 283
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ISSN: 1664-042X
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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