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DC Field | Value | Language |
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dc.contributor.author | Calvo Martín, Juan Manuel | - |
dc.contributor.author | Papaceit Vidal, Montserrat | - |
dc.contributor.author | Segarra Robert, Carmen | - |
dc.date.accessioned | 2017-02-24T12:45:13Z | - |
dc.date.available | 2017-02-24T12:45:13Z | - |
dc.date.issued | 2017-01-17 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/107388 | - |
dc.description.abstract | Drosophila CAF1-55 protein is a subunit of the Polycomb repressive complex PRC2 and other protein complexes. It is a multifunctional and evolutionarily conserved protein that participates in nucleosome assembly and remodelling, as well as in the epigenetic regulation of a large set of target genes. Here, we describe and analyze the duplication of Caf1-55 in the obscura group of Drosophila. Paralogs exhibited a strong asymmetry in evolutionary rates, which suggests that they have evolved according to a neofunctionalization process. During this process, the ancestral copy has been kept under steady purifying selection to retain the ancestral function and the derived copy (Caf1-55dup) that originated via a DNA-mediated duplication event ~18 Mya, has been under clear episodic selection. Different maximum likelihood approaches confirmed the action of positive selection, in contrast to relaxed selection, on Caf1-55dup after the duplication. This adaptive process has also taken place more recently during the divergence of D. subobscura and D. guanche. The possible association of this duplication with a previously detected acceleration in the evolutionary rate of three CAF1-55 partners in PRC2 complexes is discussed. Finally, the timing and functional consequences of the Caf1-55 duplication is compared to other duplications of Polycomb genes. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep40536 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 40536, p. 1-10 | - |
dc.relation.uri | https://doi.org/10.1038/srep40536 | - |
dc.rights | cc-by (c) Calvo-Martín, J.M. et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Molècules | - |
dc.subject.classification | Drosòfila | - |
dc.subject.other | Proteins | - |
dc.subject.other | Molecules | - |
dc.subject.other | Drosophila | - |
dc.title | Evidence of neofunctionalization after the duplication of the highly conserved Polycomb group gene Caf1-55 in the obscura group of Drosophila | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 666458 | - |
dc.date.updated | 2017-02-24T12:45:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28094282 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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666458.pdf | 685.82 kB | Adobe PDF | View/Open |
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