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Title: Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.
Author: Delgado, Julio (Delgado González)
Bielig, Torsten
Bonet, Lizette
Carnero-Montoro, Elena
Puente, Xose S.
Colomer Pujol, Dolors
Bosch, Elena
Campo Güerri, Elias
Lozano Soto, Francisco
Keywords: Leucèmia limfocítica crònica
Receptors cel·lulars
Cèl·lules B
Biologia molecular
Chronic lymphocytic leukemia
Cell receptors
B cells
Molecular biology
Issue Date: 15-Mar-2016
Publisher: Blackwell Science
Abstract: Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis.
It is part of: British Journal of Haematology, 2017, vol. 177,num. 1,p. 147-150
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ISSN: 0007-1048
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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