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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/107829
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dc.contributor.authorBosch Cartes, Joan-
dc.contributor.authorBachs, Jordi-
dc.contributor.authorGómez, Antonia M.-
dc.contributor.authorGriera Farres, Rosa-
dc.contributor.authorÉcija, Marta-
dc.contributor.authorAmat Tusón, Mercedes-
dc.date.accessioned2017-03-03T15:44:50Z-
dc.date.available2017-03-03T15:44:50Z-
dc.date.issued2012-07-20-
dc.identifier.issn0022-3263-
dc.identifier.urihttp://hdl.handle.net/2445/107829-
dc.description.abstractPractical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.-
dc.format.extent5 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/jo300925c-
dc.relation.ispartofJournal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344-
dc.relation.urihttps://doi.org/10.1021/jo300925c-
dc.rights(c) American Chemical Society , 2012-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationAntihistamínics-
dc.subject.classificationEstructura molecular-
dc.subject.classificationSíntesi orgànica-
dc.subject.otherAntihistamines-
dc.subject.otherMolecular structure-
dc.subject.otherOrganic synthesis-
dc.titleStereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec615886-
dc.date.updated2017-03-03T15:44:50Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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