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Title: Cooperative effects between arginine and glutamic acid in the amino acid catalyzed aldol reaction
Author: Valero González, Guillem
Moyano i Baldoire, Albert
Keywords: Aminoàcids
Química supramolecular
Àcid glutàmic
Amino acids
Supramolecular chemistry
Glutamic acid
Issue Date: 30-Jun-2016
Publisher: Wiley
Abstract: Catalysis of the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde by mixtures of L-Arg and of L-Glu in wet DMSO takes place with higher enantioselectivity (up to a seven-fold enhancement in the anti- aldol for the 1:1 mixture) than that observed when either L-Glu or L-Arg alone are used as the catalysts. These results can be explained by the formation of a catalytically active hydrogen-bonded complex between both amino acids, and demonstrate the possibility of positive cooperative effects in catalysis by two different α-amino acids. Chirality
Note: Versió postprint del document publicat a:
It is part of: Chirality, 2016, vol. 28, num. 8, p. 599-605
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ISSN: 0899-0042
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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