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Title: Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort study
Author: García-Basteiro, Alberto L.
Quintó, Llorenç
Macete, Eusébio
Bardají, Azucena
González, Raquel
Nhacolo, Arsénio
Sigaúque, Betuel
Sacoor, Charfudin
Rupérez, María
Sicuri, Elisa
Bassat Orellana, Quique
Sevene, Esperança Júlia Pires
Menéndez, Clara
Keywords: Mortalitat infantil
Infant mortality
Issue Date: 17-Feb-2017
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Preterm and small for gestational age (SGA) births have been associated with adverse outcomes during the first stages of life. We evaluated the morbidity and mortality associated with preterm and SGA births during the first year of life in a rural area of Southern Mozambique. METHODS: This is a retrospective cohort study using previously collected data from children born at the Manhica District Hospital in two different periods (2003-2005 and 2010-2012). Newborns were classified as being preterm and/or SGA or as babies not fulfilling any of the previous conditions (term non-SGA). All children were followed up for a year for morbidity and mortality outcomes. RESULTS: A total of 5574 live babies were included in the analysis. The prevalence of preterm delivery was 6.2% (345/5574); the prevalence of SGA was 14.0% (776/5542) and 2.2% (114/5542) of the children presented both conditions. During the neonatal period, preterm delivery and SGA were associated with 13 (HR: 13.0, 95% CI 4.0-42.2) and 5 times (HR: 4.5, 95% CI: 1.6-12.6) higher mortality compared to term non SGA babies. Risk of hospitalization was only increased when both conditions were present (IRR: 3.5, 95%CI: 1.5-8.1). Mortality is also increased during the entire first year, although at a lower rate. CONCLUSIONS: Neonatal and infant mortality rates are remarkably high among preterm and SGA babies in southern Mozambique. These increased rates are concentrated within the neonatal period. Prompt identification of these conditions is needed to implement interventions aimed at increasing survival of these high-risk newborns.
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It is part of: PLoS One, 2017, vol. 12, num. 2, p. e0172533
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)

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