Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/108002
Title: Delineating the efficacy of a cannabis-based medicine at advanced stages of dementia in a murine model
Author: Asó, Ester
Andrés-Benito, Pol
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Cànnabis
Malaltia d'Alzheimer
Demència
Cognició
Múrids
Cannabis
Alzheimer's disease
Dementia
Cognition
Muridae
Issue Date: 4-Oct-2016
Publisher: IOS Press
Abstract: Previous reports have demonstrated that the combination of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) botanical extracts, which are the components of an already approved cannabis-based medicine, reduce the Alzheimer-like phenotype of AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage. Here, we provide evidence that such natural cannabinoids are still effective in reducing memory impairment in AβPP/PS1 mice at advanced stages of the disease but are not effective in modifying the Aβ processing or in reducing the glial reactivity associated with aberrant Aβ deposition as occurs when administered at early stages of the disease. The present study also demonstrates that natural cannabinoids do not affect cognitive impairment associated with healthy aging in wild-type mice. The positive effects induced by Δ9-THC and CBD in aged AβPP/PS1 mice are associated with reduced GluR2/3 and increased levels of GABA-A Rα1 in cannabinoid-treated animals when compared with animals treated with vehicle alone.
Note: Reproducció del document publicat a: https://doi.org/10.3233/JAD-160533
It is part of: Journal of Alzheimer's Disease, 2016, vol. 54, num. 3, p. 903-912
Related resource: https://doi.org/10.3233/JAD-160533
URI: http://hdl.handle.net/2445/108002
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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