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Title: Stereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles
Author: Ghirardi, Elena
Griera Farres, Rosa
Piccichè, Miriam
Molins i Grau, Elies
Fernández Cadenas, Israel
Bosch Cartes, Joan
Amat Tusón, Mercedes
Keywords: Lactames
Síntesi asimètrica
Asymmetric synthesis
Issue Date: 18-Nov-2016
Publisher: American Chemical Society
Abstract: Cyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2- oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydroindoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2016, vol. 18, num. 22, p. 5836-5839
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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