Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/108163
Title: Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trial
Author: Colomina Soler, M. J. (María José)
Koo Gómez, Maylin
Basora Macaya, Misericordia
Pizones. J.
Mora, Lidia
Bagó, Joan
Keywords: Columna vertebral
Cirurgia operatòria
Placebos
Transfusió de sang
Medul·la espinal
Hemorràgia
Assaigs clínics
Spine
Operative surgery
Placebos (Medicine)
Blood transfusion
Spinal cord
Hemorrhage
Clinical trials
Issue Date: 16-Feb-2017
Publisher: Oxford University Press
Abstract: Background. Perioperative tranexamic acid (TXA) use can reduce bleeding and transfusion requirements in several types of surgery, but level I evidence proving its effectiveness in major spine surger y is lacking. This study was designed to investigate the hypothesis that TXA reduces perioperative blood loss and transfusion requirements in patients undergoing major spine procedures. Methods. We conducted a multicentre, prospective, randomized double -blind clinical trial, comparing TXA with placebo in posterior instrumented spine surgery. Efficacy was determined based on the total number of blood units transfused and the perioperative blood loss. Other variables such as the characteristics of surgery, length of hospital stay, and complications were also analysed. Results. Ninety-five patients undergoing posterior instrumented spine surgery (fusion of >3 segments) were enrolled and randomized: 44 received TXA (TXA group) and 51 received placebo (controls). The groups were comparable for duration of surgery, number of levels fused, and length of hospitalization. Transfusion was not required in 48% of subjects receiving TXA compared with 33% of controls (P=0.05). Mean number of blood units transfused was 0.85 in the TXA group and 1.42 with placebo (P=0.06). TXA resulted in a significant decrease in intraoperative bleeding (P=0.01) and total bleeding (P=0.01)relative to placebo. The incidence of adverse events was similar in the two groups. Conclusions. TXA did not significantly reduce transfusion requirements, but significantly reduced perioperative blood loss in adults undergoing major spinal surgery.
Note: Versió postprint del document publicat a: https://doi.org/10.1093/bja/aew434
It is part of: British Journal of Anaesthesia, 2017, vol. 118, num. 3, p. 380-390
Related resource: https://doi.org/10.1093/bja/aew434
URI: http://hdl.handle.net/2445/108163
ISSN: 0007-0912
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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