Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/108263
Title: A General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines
Author: Amat Tusón, Mercedes
Fabregat, Robert
Griera Farres, Rosa
Bosch Cartes, Joan
Keywords: Quinolones
Síntesi orgànica
Lactames
Reacció d'oxidació-reducció
Quinolone antibacterial agents
Organic synthesis
Lactams
Oxidation-reduction reaction
Issue Date: 20-Feb-2009
Publisher: American Chemical Society
Abstract: A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/jo802587h.
It is part of: Journal of Organic Chemistry, 2009, vol. 74, num. 4, p. 1794-1797
Related resource: https://doi.org/10.1021/jo802587h.
URI: http://hdl.handle.net/2445/108263
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
566015.pdf207.71 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.