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Title: A General Synthetic Route to Enantiopure 5-Substituted cis-Decahydroquinolines
Author: Amat Tusón, Mercedes
Fabregat, Robert
Griera Farres, Rosa
Bosch Cartes, Joan
Keywords: Quinolones
Síntesi orgànica
Reacció d'oxidació-reducció
Quinolone antibacterial agents
Organic synthesis
Oxidation-reduction reaction
Issue Date: 20-Feb-2009
Publisher: American Chemical Society
Abstract: A practical synthetic route to enantiopure 5-substituted cisdecahydroquinolines has been developed, the key steps being a stereoselective cyclocondensation of 2-substituted 6-oxocyclohexenepropionates 2 with (R)-phenylglycinol, the stereoselective hydrogenation of the resulting unsaturated tricyclic lactams, and the stereoselective reductive cleavage of the oxazolidine ring.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2009, vol. 74, num. 4, p. 1794-1797
Related resource:
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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