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Title: Preclinical immunomodulation by the probiotic Bifidobacterium breve M-16V in early life
Author: Rigo-Adrover, Mar
Franch i Masferrer, Àngels
Castell, Margarida
Pérez-Cano, Francisco J.
Keywords: Suplements nutritius
Sistema immunològic
Rates (Animals de laboratori)
Dietary supplements
Immune system
Rats as laboratory animals
Issue Date: 7-Nov-2016
Publisher: Public Library of Science (PLoS)
Abstract: This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained. The probiotic supplementation in early life did not modify the growth curve and did not enhance the systemic immune maturation. However, it increased the proportion of cells bearing TLR4 in the MLN and IEL, and enhanced the percentage of the integrin αEβ7+ and CD62L+ cells in the MLN and that of the integrin αEβ7+ cells in the IEL, suggesting an enhancement of the homing process of naïve T lymphocytes to the MLN, and the retention of activated lymphocytes in the intraepithelial compartment. Interestingly, B. breve M-16V enhanced the intestinal IgA synthesis. In conclusion, supplementation with the probiotic strain B. breve M-16V during suckling improves the development of mucosal immunity in early life
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It is part of: PLoS One, 2016, vol. 11, num. 11, p. e0166082
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

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