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http://hdl.handle.net/2445/108593
Title: | Regulation of N-Myc downstream regulated gene 2 by bile acids |
Author: | Langhi, Cédric Pedraz Cuesta, Elena Donate, Yolanda Marrero González, Pedro F. Haro Bautista, Diego Rodríguez Rubio, Joan Carles |
Keywords: | Àcids biliars Receptors nuclears (Bioquímica) Càncer Metabolisme Ronyó Regulació genètica Proteïnes Bile acids Nuclear receptors (Biochemistry) Cancer Metabolism Kidney Genetic regulation Proteins |
Issue Date: | 26-Apr-2013 |
Publisher: | Elsevier B.V. |
Abstract: | Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpre ssion of a constitutively active form of FXR increased NDRG2 expression. A FXR-response element was identified within intronic regions of human and murine genes. Moreover, mice given GW4064 exhib it an increase of Ndrg2 expression in liver and kidney, where both NDRG2 and FXR are enriched. The identification of NDRG2 as a bile acid regulated gene may provide novel knowledge toward the understanding of NDRG2 physiological function and the link between metabolism and cancer. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.bbrc.2013.03.058 |
It is part of: | Biochemical and Biophysical Research Communications, 2013, vol. 434, num. 1, p. 102-109 |
URI: | http://hdl.handle.net/2445/108593 |
Related resource: | https://doi.org/10.1016/j.bbrc.2013.03.058 |
ISSN: | 0006-291X |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
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