Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/108593
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Langhi, Cédric | - |
dc.contributor.author | Pedraz Cuesta, Elena | - |
dc.contributor.author | Donate, Yolanda | - |
dc.contributor.author | Marrero González, Pedro F. | - |
dc.contributor.author | Haro Bautista, Diego | - |
dc.contributor.author | Rodríguez Rubio, Joan Carles | - |
dc.date.accessioned | 2017-03-17T16:41:22Z | - |
dc.date.available | 2017-03-17T16:41:22Z | - |
dc.date.issued | 2013-04-26 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/2445/108593 | - |
dc.description.abstract | Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpre ssion of a constitutively active form of FXR increased NDRG2 expression. A FXR-response element was identified within intronic regions of human and murine genes. Moreover, mice given GW4064 exhib it an increase of Ndrg2 expression in liver and kidney, where both NDRG2 and FXR are enriched. The identification of NDRG2 as a bile acid regulated gene may provide novel knowledge toward the understanding of NDRG2 physiological function and the link between metabolism and cancer. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.bbrc.2013.03.058 | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications, 2013, vol. 434, num. 1, p. 102-109 | - |
dc.relation.uri | https://doi.org/10.1016/j.bbrc.2013.03.058 | - |
dc.rights | (c) Elsevier B.V., 2013 | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Àcids biliars | - |
dc.subject.classification | Receptors nuclears (Bioquímica) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Ronyó | - |
dc.subject.classification | Regulació genètica | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Bile acids | - |
dc.subject.other | Nuclear receptors (Biochemistry) | - |
dc.subject.other | Cancer | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Kidney | - |
dc.subject.other | Genetic regulation | - |
dc.subject.other | Proteins | - |
dc.title | Regulation of N-Myc downstream regulated gene 2 by bile acids | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 626568 | - |
dc.date.updated | 2017-03-17T16:41:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
626568.pdf | 752.64 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.