Please use this identifier to cite or link to this item:
Title: Modulation of irisin and physical activity on executive functions in obesity and morbid obesity
Author: Fagundo, Ana Beatriz
Jiménez-Murcia, Susana
Giner Bartolomé, Cristina
Agüera, Zaida
Sauchelli, Sarah
Pardo, M.
Crujeiras, Ana B.
Granero, Roser
Baños Rivera, Rosa María
Botella Arbona, Cristina
Torre Fornell, Rafael de la
Fernández-Real Lemos, José Manuel
Fernández García, José C.
Frühbeck, Gema
Rodríguez, Amaia
Mallorquí-Bagué, Núria
Tárrega, Salomé
Tinahones, Francisco J.
Rodríguez, Roser
Ortega, Francisco Javier
Menchón Magriñá, José Manuel
Casanueva, Felipe F.
Fernández Aranda, Fernando
Keywords: Hormones
Condició física
Obesitat mòrbida
Physical fitness
Morbid obesity
Issue Date: 1-Aug-2016
Publisher: Nature Publishing Group
Abstract: Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2016, vol. 6, p. 30820
Related resource:
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
669382.pdf480.8 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons