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Title: | Symptomatic profiles of 1334 polycythemia vera patients: implications of inadequately controlled disease |
Author: | Geyer, Holly L. Scherber, Robyn Kosiorek, Heidi Dueck, Amylou C. Kiladjian, Jean-Jacques Xiao, Zhijian Slot, Stefanie Zweegman, Sonja Sackmann, Federico Kerguelen Fuentes, Ana Hernández-Maraver, Dolores Döhner, Konstanze Harrison, Claire N. Radia, Deepti Muxi, Pablo Besses, Carlos Cervantes Requena, F. Johansson, Peter L. Andreasson, Bjorn Rambaldi, Alessandro Barbui, Tiziano Bonatz, Karin Reiter, Andreas Boyer, Francoise Etienne, Gabriel Ianotto, Jean-Christophe Ranta, Dana Roy, Lydia Cahn, Jean-Yves Maldonado, Norman Barosi, Giovanni Ferrari, Maria L. Gale, Robert Peter Birgegard, Gunnar Xu, Zefeng Zhang, Yue Sun, Xiujuan Xu, Junqing Zhang, Peihong Te Boekhorst, Peter A. Commandeur, Suzan Schouten, Harry C. Pahl, Heike L. Griesshammer, Martin Stegelmann, Frank Lehmann, Thomas Senyak, Zhenya Vannucchi, Alessandro M. Passamonti, Francesco Samuelsson, Jan Mesa, Ruben A. |
Keywords: | Hematologia Oncologia Medul·la òssia Malalties hematològiques Hematology Oncology Bone marrow Hematologic diseases |
Issue Date: | 1-Jan-2016 |
Publisher: | American Society of Clinical Oncology |
Abstract: | Purpose Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) associated with disabling symptoms and a heightened risk of life-threatening complications. Recent studies have demonstrated the effectiveness of JAK inhibitor therapy in patients with PV patients who have a history of prior hydroxyurea (HU) use (including resistance or intolerance), phlebotomy requirements, and palpable splenomegaly. We aimed to determine how these features contribute alone and in aggregate to the PV symptom burden. Patients and Methods Through prospective evaluation of 1,334 patients with PV who had characterized symptom burden, we assessed patient demographics, laboratory data, and the presence of splenomegaly by disease feature (ie, known HU use, known phlebotomy requirements, splenomegaly). Results The presence of each feature in itself is associated with a moderately high symptom burden (MPN symptom assessment form [SAF] total symptom score [TSS] range, 27.7 to 29.2) that persists independent of PV risk category. In addition, symptoms incrementally increase in severity with the addition of other features. Patients with PV who had all three features (PV-HUPS) faced the highest total score (MPN-SAF TSS, 32.5) but had similar individual symptom scores to patients with known HU use (PV-HU), known phlebotomy (PV-P), and splenomegaly (PV-S). Conclusion The results of this study suggest that patients with PV who have any one of the features in question (known HU use, known phlebotomy, or splenomegaly) have significant PV-associated symptoms. Furthermore, it demonstrates that many PV symptoms remain severe independent of the number of features present. |
Note: | Reproducció del document publicat a: https://doi.org/10.1200/JCO.2015.62.9337 |
It is part of: | Journal of Clinical Oncology, 2016, vol. 34, num. 2, p. 151-159 |
URI: | http://hdl.handle.net/2445/108895 |
Related resource: | https://doi.org/10.1200/JCO.2015.62.9337 |
ISSN: | 0732-183X |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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