Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/108962
Title: Brain metabolism during hallucination-like auditory stimulation in schizophrenia.
Author: Horga, Guillermo
Fernández-Egea, Emilio
Mané Santacana, Anna
Font Planells, Mireia
Schatz, Kelly C.
Falcón, Carles
Lomeña Caballero, Francisco Juan
Bernardo Arroyo, Miquel
Parellada Rodón, Eduard
Keywords: Al·lucinacions i il·lusions
Trastorns auditius
Esquizofrènia
Tomografia
Cos amigdaloide
Hallucinations and illusions
Hearing disorders
Schizophrenia
Tomography
Amygdaloid body
Issue Date: 8-Jan-2014
Publisher: Public Library of Science (PLoS)
Abstract: Auditory verbal hallucinations (AVH) in schizophrenia are typically characterized by rich emotional content. Despite the prominent role of emotion in regulating normal perception, the neural interface between emotion-processing regions such as the amygdala and auditory regions involved in perception remains relatively unexplored in AVH. Here, we studied brain metabolism using FDG-PET in 9 remitted patients with schizophrenia that previously reported severe AVH during an acute psychotic episode and 8 matched healthy controls. Participants were scanned twice: (1) at rest and (2) during the perception of aversive auditory stimuli mimicking the content of AVH. Compared to controls, remitted patients showed an exaggerated response to the AVH-like stimuli in limbic and paralimbic regions, including the left amygdala. Furthermore, patients displayed abnormally strong connections between the amygdala and auditory regions of the cortex and thalamus, along with abnormally weak connections between the amygdala and medial prefrontal cortex. These results suggest that abnormal modulation of the auditory cortex by limbic-thalamic structures might be involved in the pathophysiology of AVH and may potentially account for the emotional features that characterize hallucinatory percepts in schizophrenia
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0084987
It is part of: PLoS One, 2014, vol. 9, num. 1, p. e84987
Related resource: https://doi.org/10.1371/journal.pone.0084987
URI: http://hdl.handle.net/2445/108962
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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