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|Title:||Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study|
|Author:||Ibánez Sanz, Gemma|
Díez Villanueva, Anna
Henar Alonso, M.
Rodríguez Moranta, Francisco
Pérez Gómez, Beatriz
Bustamante Pineda, Mariona
Llorca Díaz, Javier
Jiménez Moleón, José J.
Fernández Navarro, Pablo
Dávila Batista, Verónica
Molina, Antonio José
Qualitat de vida
Quality of life
|Abstract:||Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1038/srep43263|
|It is part of:||Scientific Reports, 2017, vol. 7, num. 43263|
|Appears in Collections:||Articles publicats en revistes (ISGlobal)|
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