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Title: Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study
Author: Ibáñez Sanz, Gemma
Díez Villanueva, Anna
Alonso, M. Henar
Rodríguez Moranta, Francisco
Pérez Gómez, Beatriz
Bustamante Pineda, Mariona
Martin, Vicente
Llorca Díaz, Javier
Amiano, Pilar
Ardanaz, Eva
Tardón, Adonina
Jiménez Moleón, José Juan
Peiró Pérez, Rosana
Alguacil, Juan
Navarro, Carmen
Guinó, Elisabet
Binefa, Gemma
Fernández Navarro, Pablo
Espinosa, Ana
Dávila Batista, Verónica
Molina, Antonio José
Palazuelos-Calderón, Camilo
Castaño-Vinyals, Gemma
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Moreno, Víctor
Keywords: Càncer colorectal
Qualitat de vida
Colorectal cancer
Quality of life
Issue Date: 24-Feb-2017
Publisher: Macmillan
Abstract: Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
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It is part of: Scientific Reports, 2017, vol. 7, num. 43263
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (ISGlobal)

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