Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/109052
Title: Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
Author: Sangüesa Puigventós, Gemma
Shaligram, Sonali
Akther, Farjana
Roglans i Ribas, Núria
Laguna Egea, Juan Carlos
Rahimian, Roshanak
Alegret i Jordà, Marta
Keywords: Fructosa
Glucosa
Fetge
Resistència a la insulina
Proteïnes de la sang
Trastorns del metabolisme
Fructose
Glucose
Liver
Insulin resistance
Blood proteins
Disorders of metabolism
Issue Date: 1-Feb-2017
Publisher: American Physiological Society
Abstract: High consumption of simple sugars causes adverse cardiometabolic effects. We investigated the mechanisms underlying the metabolic and vascular effects of glucose or fructose intake and determined whether these effects are exclusively related to increased calorie consumption. Female Sprague-Dawley rats were supplemented with 20% wt/vol glucose or fructose for 2 mo, and plasma analytes and aortic response to vasodilator and vasoconstrictor agents were determined. Expression of molecules associated with lipid metabolism, insulin signaling, and vascular response were evaluated in hepatic and/or aortic tissues. Caloric intake was increased in both sugar-supplemented groups vs. control and in glucose- vs. fructose-supplemented rats. Hepatic lipogenesis was induced in both groups. Plasma triglycerides were increased only in the fructose group, together with decreased expression of carnitine palmitoyltransferase-1A and increased microsomal triglyceride transfer protein expression in the liver. Plasma adiponectin and peroxisome proliferator-activated receptor (PPAR)-α expression was increased only by glucose supplementation. Insulin signaling in liver and aorta was impaired in both sugar-supplemented groups, but the effect was more pronounced in the fructose group. Fructose supplementation attenuated aortic relaxation response to a nitric oxide (NO) donor, whereas glucose potentiated it. Phenylephrine-induced maximal contractions were reduced in the glucose group, which could be related to increased endothelial NO synthase (eNOS) phosphorylation and subsequent elevated basal NO in the glucose group. In conclusion, despite higher caloric intake in glucose-supplemented rats, fructose caused worse metabolic and vascular responses. This may be because of the elevated adiponectin level and the subsequent enhancement of PPARα and eNOS phosphorylation in glucose-supplemented rats.
Note: Versió postprint del document publicat a: https://doi.org/10.1152/ajpheart.00339.2016
It is part of: American Journal of Physiology-Heart and Circulatory Physiology, 2017, vol. 312, num. 2, p. H289-H304
Related resource: https://doi.org/10.1152/ajpheart.00339.2016
URI: http://hdl.handle.net/2445/109052
ISSN: 0363-6135
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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