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Title: Comparative genomics of the Aeromonadaceae core oligosaccharide biosynthetic regions.
Author: Forn-Cuní, Gabriel
Tomás, Juan M.
Merino Montero, Susana
Keywords: Genètica bacteriana
Bacteris patògens
Bacterial genetics
Pathogenic bacteria
Issue Date: 28-Feb-2017
Publisher: MDPI
Abstract: Lipopolysaccharides (LPSs) are an integral part of the Gram-negative outer membrane, playing important organizational and structural roles and taking part in the bacterial infection process. In Aeromonas hydrophila, piscicola, and salmonicida, three different genomic regions taking part in the LPS core oligosaccharide (Core-OS) assembly have been identified, although the characterization of these clusters in most aeromonad species is still lacking. Here, we analyse the conservation of these LPS biosynthesis gene clusters in the all the 170 currently public Aeromonas genomes, including 30 different species, and characterise the structure of a putative common inner Core-OS in the Aeromonadaceae family. We describe three new genomic organizations for the inner Core-OS genomic regions, which were more evolutionary conserved than the outer Core-OS regions, which presented remarkable variability. We report how the degree of conservation of the genes from the inner and outer Core-OS may be indicative of the taxonomic relationship between Aeromonas species.
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It is part of: International Journal of Molecular Sciences, 2017, vol. 18, p. 519-531
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ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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