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DC Field | Value | Language |
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dc.contributor.author | Cristelli, M. P. | - |
dc.contributor.author | Cofán Pujol, Federico | - |
dc.contributor.author | Rico, N. | - |
dc.contributor.author | Trullás Vila, Joan Carles | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Agüero Santangelo, Fernando | - |
dc.contributor.author | Bedini, J. L. | - |
dc.contributor.author | Moreno Camacho, Ma. Asunción | - |
dc.contributor.author | Oppenheimer Salinas, Federico | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.date.accessioned | 2017-04-05T14:07:25Z | - |
dc.date.available | 2017-04-05T14:07:25Z | - |
dc.date.issued | 2017-02-10 | - |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | http://hdl.handle.net/2445/109424 | - |
dc.description.abstract | Background Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods Cross-sectional, single center study including adult patients with HIV-infection. Results Four thousand five hundred three patients with HIV-infection (864 women; 19%) were examined. Median age was 45 years (IQR 37-52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82-1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/1.73 m2 for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as "mild reduced GFR" who were classified as "normal function" with CKD-EPI. Using CKD-EPI, it was possible to identify "normal function" (>90 mL/min/1.73 m2) in 73% patients and "mild reduced GFR" (60-89 mL/min/1.73 m2) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m2 with MDRD. Conclusions There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60-89 mL/min/1.73 m2). | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12882-017-0470-4 | - |
dc.relation.ispartof | BMC Nephrology, 2017, vol. 18, num. 1, p. 58 | - |
dc.relation.uri | https://doi.org/10.1186/s12882-017-0470-4 | - |
dc.rights | cc-by (c) Cristelli, M.P. et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Persones seropositives | - |
dc.subject.classification | Malalties del ronyó | - |
dc.subject.classification | Nefrologia | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | HIV-positive persons | - |
dc.subject.other | Kidney diseases | - |
dc.subject.other | Nephrology | - |
dc.title | Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 669001 | - |
dc.date.updated | 2017-04-05T14:07:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28183270 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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