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http://hdl.handle.net/2445/109602
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DC Field | Value | Language |
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dc.contributor.author | Kawana-Tachikawa, Ai | - |
dc.contributor.author | Llibre, Josep María | - |
dc.contributor.author | Bravo, Isabel | - |
dc.contributor.author | Escrig, Roser | - |
dc.contributor.author | Mothe, Beatriz | - |
dc.contributor.author | Puig, Jordi | - |
dc.contributor.author | Puertas, Maria C. | - |
dc.contributor.author | Martínez Picado, Francisco Javier | - |
dc.contributor.author | Blanco, Julià | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Iwamoto, Aikichi | - |
dc.contributor.author | Pozniak, Anton L. | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Brander, Christian | - |
dc.date.accessioned | 2017-04-11T06:49:06Z | - |
dc.date.available | 2017-04-11T06:49:06Z | - |
dc.date.issued | 2014-01-27 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/109602 | - |
dc.description.abstract | BACKGROUND: The effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown. METHODS: Subjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc intensification for 48 weeks, and were monitored up to week 60. PBMC and in vitro-expanded T cells were tested for responses to the entire HIV proteome by ELISpot analyses. Intracellular cytokine staining assays were conducted to monitor the (poly)-functionality of HIV-1-specific T cells. Analyses were performed at baseline and week 24 after treatment start, and at week 60 (3 months after maraviroc discontinuation). RESULTS: Maraviroc intensification was associated with a slower decay of virus-specific T cell responses over time compared to the non-intensified regimen in both direct ex-vivo as well as in in-vitro expanded cells. The effector function profiles of virus-specific CD8⁺ T cells were indistinguishable between the two arms and did not change over time between the groups. CONCLUSIONS: Maraviroc did not negatively impact any of the measured parameters, but was rather associated with a prolonged maintenance of HIV-1-specific T cell responses. Maraviroc, in addition to its original effect as viral entry inhibitor, may provide an additional benefit on the maintenance of virus-specific T cells which may be especially important for future viral eradication strategies. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0087334 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 1, p. e87334 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0087334 | - |
dc.rights | cc-by (c) Kawana-Tachikawa, Ai et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Resposta immunitària | - |
dc.subject.classification | Genètica molecular | - |
dc.subject.other | T cells | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | Immune response | - |
dc.subject.other | Molecular genetics | - |
dc.title | Effect of Maraviroc intensification on HIV-1-specific T cell immunity in recently HIV-1-infected individuals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 641597 | - |
dc.date.updated | 2017-04-11T06:49:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24475275 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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641597.pdf | 844.68 kB | Adobe PDF | View/Open |
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