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http://hdl.handle.net/2445/109782
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DC Field | Value | Language |
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dc.contributor.author | Prieto González, Sergio | - |
dc.contributor.author | Depetris, Marina | - |
dc.contributor.author | García Martínez, Ana | - |
dc.contributor.author | Espígol Frigolé, Georgina | - |
dc.contributor.author | Tavera Bahillo, Itziar | - |
dc.contributor.author | Corbera Bellalta, Marc | - |
dc.contributor.author | Planas Rigol, Ester | - |
dc.contributor.author | Alba Garibay, Marco Antonio | - |
dc.contributor.author | Hernández Rodríguez, José | - |
dc.contributor.author | Grau Junyent, Josep M. (Josep Maria) | - |
dc.contributor.author | Lomeña Caballero, Francisco Juan | - |
dc.contributor.author | Cid Xutglà, M. Cinta | - |
dc.date.accessioned | 2017-04-19T10:05:12Z | - |
dc.date.available | 2017-04-19T10:05:12Z | - |
dc.date.issued | 2014-07-01 | - |
dc.identifier.issn | 0003-4967 | - |
dc.identifier.uri | http://hdl.handle.net/2445/109782 | - |
dc.description.abstract | BACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2013-204572 | - |
dc.relation.ispartof | Annals of the Rheumatic Diseases, 2014, vol. 73, num. 7, p. 1388-1392 | - |
dc.relation.uri | https://doi.org/10.1136/annrheumdis-2013-204572 | - |
dc.rights | (c) BMJ Publishing Group, 2014 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Arteritis de cèl·lules gegants | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Tomografia computada per emissió de fotó simple | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Giant cell arteritis | - |
dc.subject.other | Cancer | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Single-photon emission computed tomography | - |
dc.subject.other | Case studies | - |
dc.title | Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 642896 | - |
dc.date.updated | 2017-04-19T10:05:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24665112 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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642896.pdf | 448.63 kB | Adobe PDF | View/Open |
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