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dc.contributor.authorPrieto González, Sergio-
dc.contributor.authorDepetris, Marina-
dc.contributor.authorGarcía Martínez, Ana-
dc.contributor.authorEspígol Frigolé, Georgina-
dc.contributor.authorTavera Bahillo, Itziar-
dc.contributor.authorCorbera Bellalta, Marc-
dc.contributor.authorPlanas Rigol, Ester-
dc.contributor.authorAlba Garibay, Marco Antonio-
dc.contributor.authorHernández Rodríguez, José-
dc.contributor.authorGrau Junyent, Josep M. (Josep Maria)-
dc.contributor.authorLomeña Caballero, Francisco Juan-
dc.contributor.authorCid Xutglà, M. Cinta-
dc.description.abstractBACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis.-
dc.format.extent6 p.-
dc.publisherBMJ Publishing Group-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofAnnals of the Rheumatic Diseases, 2014, vol. 73, num. 7, p. 1388-1392-
dc.rights(c) BMJ Publishing Group, 2014-
dc.subject.classificationArteritis de cèl·lules gegants-
dc.subject.classificationTomografia computada per emissió de fotó simple-
dc.subject.classificationEstudi de casos-
dc.subject.otherGiant cell arteritis-
dc.subject.otherSingle-photon emission computed tomography-
dc.subject.otherCase studies-
dc.titlePositron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study-
Appears in Collections:Articles publicats en revistes (Medicina)

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