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Title: Positron emission tomography assessment of large vessel inflammation in patients with newly diagnosed, biopsy-proven giant cell arteritis: a prospective, case-control study
Author: Prieto González, Sergio
Depetris, Marina
García Martínez, Ana
Espígol Frigolé, Georgina
Tavera Bahillo, Itziar
Corbera Bellalta, Marc
Planas Rigol, Ester
Alba Garibay, Marco Antonio
Hernández Rodríguez, José
Grau Junyent, Josep M. (Josep Maria)
Lomeña Caballero, Francisco Juan
Cid Xutglà, M. Cinta
Keywords: Arteritis de cèl·lules gegants
Tomografia computada per emissió de fotó simple
Estudi de casos
Giant cell arteritis
Single-photon emission computed tomography
Case studies
Issue Date: 1-Jul-2014
Publisher: BMJ Publishing Group
Abstract: BACKGROUND: Positron emission tomography (PET) scan is emerging as a promising imaging technique to detect large-vessel inflammation in giant cell arteritis (GCA). However, the lack of a standardised definition of arteritis based on (18)fluorodeoxyglucose (FDG) uptake is an important limitation to the use of PET scan for diagnostic purposes. OBJECTIVE: To prospectively assess the intensity and distribution of FDG uptake at different vascular territories in patients with newly diagnosed GCA compared with controls. METHODS: 32 consecutive, biopsy-proven, GCA patients treated with glucocorticoids for ≤3 days were included. The control group consisted of 20 individuals, who underwent PET/CT for cancer staging. Maximal standardised uptake value (SUVm) was calculated at four aortic segments, supraaortic branches and iliac-femoral territory. Sensitivity and specificity was calculated by receiver-operator characteristic curves (ROC) analysis. RESULTS: Mean SUVm was significantly higher in patients than in controls in all vessels explored and correlated with acute-phase reactants and serum IL-6. Mean of the SUVm at all the vascular territories had an area under the curve (AUC) of 0.830, and a cut-off of 1.89 yielded a sensitivity of 80% and a specificity of 79% for GCA diagnosis. There were no significant differences in AUC among the vascular beds examined. CONCLUSIONS: FDG uptake by large vessels has a substantial sensitivity and specificity for GCA diagnosis.
Note: Reproducció del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 2014, vol. 73, num. 7, p. 1388-1392
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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