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http://hdl.handle.net/2445/109785
Title: | Stabilization of telomeric i-motif structures by (2'S)-2'-deoxy-2'-C-methyl-cytidine residues |
Author: | Aviñó Andrés, Anna Dellafiore, Maria Gargallo Gómez, Raimundo González, Carlos Iribarren, Adolfo M. Montserrat, Javier Eritja i Casadellà, Ramon |
Keywords: | Àcids nucleics Oligonucleòtids G-estructures Nucleic acids Oligonucleotides G-structures |
Issue Date: | 13-Apr-2017 |
Publisher: | Wiley-VCH |
Abstract: | G-quadruplex and i-motif are tetraplex structures present in telomeres and promoter regions of oncogenes. The possibility of producing nanodevices with pH-sensitive functions has triggered the interest for modified oligonucleotides with improved structural properties. We synthesized C-rich oligonucleotides carrying conformationally restricted (2'S)-2'-deoxy-2'-C-methyl-cytidine units. The effect of this modified nucleoside on the stability of intramolecular i-motifs related to vertebrate telomere was investigated by means of spectroscopic methods (UV, CD and NMR). The replacement of selected positions of the C-core by the appropriate C-modified residues induces the formation of stable intercalated tetraplexes at pHs near neutrality. The study demonstrates the possibility of enhancing the stability of i-motif by chemical modifications. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/cbic.201700112 |
It is part of: | ChemBioChem, 2017 |
URI: | http://hdl.handle.net/2445/109785 |
Related resource: | https://doi.org/10.1002/cbic.201700112 |
ISSN: | 1439-4227 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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