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Title: Stabilization of telomeric i-motif structures by (2'S)-2'-deoxy-2'-C-methyl-cytidine residues
Author: Aviñó Andrés, Anna
Dellafiore, Maria
Gargallo Gómez, Raimundo
González, Carlos
Iribarren, Adolfo M.
Montserrat, Javier
Eritja i Casadellà, Ramon
Keywords: Àcids nucleics
Nucleic acids
Issue Date: 13-Apr-2017
Publisher: Wiley-VCH
Abstract: G-quadruplex and i-motif are tetraplex structures present in telomeres and promoter regions of oncogenes. The possibility of producing nanodevices with pH-sensitive functions has triggered the interest for modified oligonucleotides with improved structural properties. We synthesized C-rich oligonucleotides carrying conformationally restricted (2'S)-2'-deoxy-2'-C-methyl-cytidine units. The effect of this modified nucleoside on the stability of intramolecular i-motifs related to vertebrate telomere was investigated by means of spectroscopic methods (UV, CD and NMR). The replacement of selected positions of the C-core by the appropriate C-modified residues induces the formation of stable intercalated tetraplexes at pHs near neutrality. The study demonstrates the possibility of enhancing the stability of i-motif by chemical modifications.
Note: Versió postprint del document publicat a:
It is part of: ChemBioChem, 2017
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ISSN: 1439-4227
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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