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Title: P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion
Author: Prades, Amparo
Núñez-Pertíñez, Samuel
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Lligands
Catàlisi asimètrica
Enantioselective catalysis
Issue Date: 31-Mar-2017
Publisher: Royal Society of Chemistry
Abstract: The synthesis of P-stereogenic bisphosphine ligands starting from a phosphinous acid chiral synthon and hydrazine is reported. The dialkylation of the hydrazine backbone yielded atropo- and nitrogeninversion isomers which are in slow exchange. The crystallization of one of the isomers allowed us to study the reaction kinetics of the equilibria. The new ligands were tested in the Rh catalysed asymmetric hydrogenation of various benchmark substrates attaining up to 99% ee.
Note: Reproducció del document publicat a:
It is part of: Chemical Communications, 2017, vol. 53, p. 4605-4608
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ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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