Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/110064
Title: p38MAPK and Chemotherapy: We always need to hear both Sides of the Story
Author: García-Cano, Jesús
Roche, Olga
Cimas, Francisco J.
Pascual-Serra, Raquel
Ortega-Muelas, Marta
Fernández-Aroca, Diego M.
Sánchez-Prieto, Ricardo
Keywords: Proteïnes quinases
Quimioteràpia
Càncer
Quimioteràpia del càncer
Cisplatí
Medicaments antineoplàstics
Protein kinases
Chemotherapy
Cancer
Cancer chemotherapy
Cisplatin
Antineoplastic agents
Issue Date: 30-Jun-2016
Publisher: Frontiers Media
Abstract: The p38MAPK signaling pathway was initially described as a stress response mechanism. In fact, during previous decades, it was considered a pathway with little interest in oncology especially in comparison with other MAPKs such as ERK1/2, known to be target of oncogenes like Ras. However, its involvement in apoptotic cell death phenomena makes this signaling pathway more attractive for many cancer research laboratories. This apoptotic role allows to establish a link between p38MAPK and regular chemotherapeutic agents such as Cisplatin or base analogs (Cytarabine, Gemcitabine or 5-Fluorouracil) which are currently used in hospitals across the world. In fact, and more recently, p38MAPK has also been connected with targeted therapies like tyrosine kinase inhibitors (vg. Imatinib, Sorafenib) and, to a lesser extent, with monoclonal antibodies. In addition, the oncogenic or tumor suppressor potential of this signaling pathway has aroused the interest of the scientific community in evaluating p38MAPK as a novel target for cancer therapy. In this review, we will summarize the role of p38MAPK in chemotherapy as well as the potential that p38MAPK inhibition can bring to cancer therapy. All the evidences suggest that p38MAPK could be a double-edged sword and that the search for the most appropriate candidate patients, depending on their pathology and treatment, will lead to a more rational use of this new therapeutic tool.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fcell.2016.00069
It is part of: Frontiers in Cell and Developmental Biology, 2016, vol. 4, p. 69
Related resource: https://doi.org/10.3389/fcell.2016.00069
URI: http://hdl.handle.net/2445/110064
ISSN: 2296-634X
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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