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Title: Renal Transplantation in Systemic Lupus Erythematosus: Outcome and Prognostic Factors in 50 cases from a Single Centre.
Author: Cairoli, Ernesto
Sánchez-Marcos, Carolina
Espinosa Garriga, Gerard
Glucksmann, Constanza
Ercilla González, M. Guadalupe
Oppenheimer Salinas, Federico
Cervera i Segura, Ricard, 1960-
Keywords: Lupus eritematós
Insuficiència renal crònica
Trasplantament renal
Empelts de teixits
Rebuig (Biologia)
Lupus erythematosus
Chronic renal failure
Kidney transplantation
Tissue transplantation
Graft rejection
Issue Date: 11-Jun-2014
Publisher: Hindawi
Abstract: Background. End-stage renal disease (ESRD) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Objectives. To analyze the outcome and prognostic factors of renal transplantation in patients with ESRD due to SLE from January 1986 to December 2013 in a single center. Results. Fifty renal transplantations were performed in 40 SLE patients (32 female (80%), mean age at transplantation 36 ± 10.4 years). The most frequent lupus nephropathy was type IV (72.2%). Graft failure occurred in a total of 15 (30%) transplantations and the causes of graft failure were chronic allograft nephropathy (), acute rejection (), and chronic humoral rejection (1). The death-censored graft survival rates were 93.9% at 1 year, 81.5% at 5 years, and 67.6% at the end of study. The presence of deceased donor allograft () and positive anti-HCV antibodies () negatively influence the survival of the renal transplant. The patient survival rate was 91.4% at the end of the study. Recurrence of lupus nephritis in renal allograft was observed in one patient. Conclusion. Renal transplantation is a good alternative for renal replacement therapy in patients with SLE. In our cohort, the presence of anti-HCV antibodies and the type of donor source were related to the development of graft failure.
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It is part of: BioMed Research International, 2014, vol. 2014
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ISSN: 2314-6133
Appears in Collections:Articles publicats en revistes (Medicina)

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