Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/110123
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sánchez-Escuredo, Ana | - |
dc.contributor.author | Barajas, Alberto | - |
dc.contributor.author | Revuelta, Ignacio | - |
dc.contributor.author | Blasco, Miguel | - |
dc.contributor.author | Cofán Pujol, Federico | - |
dc.contributor.author | Esforzado Armengol, Nuria | - |
dc.contributor.author | Ricart Brulles, Ma. José | - |
dc.contributor.author | Torregrosa Prats, José Vicente | - |
dc.contributor.author | Campistol Plana, Josep M. | - |
dc.contributor.author | Oppenheimer Salinas, Federico | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.date.accessioned | 2017-04-25T14:43:08Z | - |
dc.date.available | 2017-04-25T14:43:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0211-6995 | - |
dc.identifier.uri | http://hdl.handle.net/2445/110123 | - |
dc.description.abstract | From a theoretical point of view, an alloimmune response can not take place, still some type of standard immunosuppression is used in about 60% of patients receiving kidney grafts from their monozygotic twins. We aimed at assessing clinical response in patients receiving renal grafts from a living monozygotic twin donor when no immunosuppressive therapy is used. METHODS: This is a retrospective observational study of patients receiving kidney grafts from their monozygotic twins from 1969 to 2013. The following data were recorded: age, renal graft recipient's primary disease, renal function, renal survival and overall survival. Immunosuppressive therapy included a single intraoperative dose of methylprednisolone 500 mg and no maintenance immunosuppression. RESULTS: Five patients with kidney grafts from their monozygotic twins were dentified in our centre. Mean age at transplantation was 33 years (27-39). One-year overall survival and graft survival were 100%. Mean creatinine level was 0.96 ± 0.2 one year after transplantation, and 1.2 ± 0.37 mg/dl at most recent follow-up. Two patients died with a functional graft more than 15 years after kidney transplantation (causes were melanoma and cardiovascular event respectively). Follow-up was lost in a patient one year after transplantation. Two patients are alive with a functioning graft at 18 months and 42.5 years after transplantation respectively. CONCLUSION: Kidney transplantation from a living monozygotic twin is associated to outstanding clinical outcomes. Immunossuppresive therapy to suppress alloimmune response in probably unnecessary 11 zygosity has been confirmed. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier España | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.nefro.2015.06.006 | - |
dc.relation.ispartof | Nefrología, 2015, vol. 35, num. 4, p. 358-362 | - |
dc.relation.uri | https://doi.org/10.1016/j.nefro.2015.06.006 | - |
dc.rights | cc-by-nc-nd (c) Sociedad Española de Nefrología, 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Immunosupressió | - |
dc.subject.classification | Bessons | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Immunosuppression | - |
dc.subject.other | Twins | - |
dc.title | Kidney transplant from a living monozygotic twin donor with no maintenance immunosuppression. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668250 | - |
dc.date.updated | 2017-04-25T14:43:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26306949 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
668250.pdf | 243.92 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License