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Title: Coassembly and coupling of SK2 channels and mGlu5 receptors
Author: García-Negredo, Gloria
Soto del Cerro, David
Llorente, Javier
Morató Arús, Xavier
Galenkamp, Koen M.O.
Gómez-Soler, Maricel
Fernández Dueñas, Víctor
Watanabe, Masahiko
Adelman, John P.
Shigemoto, Ryuichi
Fukazawa, Yugo
Luján, Rafael
Ciruela Alférez, Francisco
Keywords: Canals de potassi
Hipocamp (Cervell)
Rates (Animals de laboratori)
Potassium channels
Hippocampus (Brain)
Rats as laboratory animals
Issue Date: 29-Oct-2014
Publisher: The Society for Neuroscience
Abstract: Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly.
Note: Reproducció del document publicat a:
It is part of: Journal of Neuroscience, 2014, vol. 34, num. 44, p. 14793-14802
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ISSN: 0270-6474
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Biomedicina)

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