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http://hdl.handle.net/2445/110442
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DC Field | Value | Language |
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dc.contributor.author | García-Negredo, Gloria | - |
dc.contributor.author | Soto del Cerro, David | - |
dc.contributor.author | Llorente, Javier | - |
dc.contributor.author | Morató Arús, Xavier | - |
dc.contributor.author | Galenkamp, Koen M.O. | - |
dc.contributor.author | Gómez Soler, Maricel | - |
dc.contributor.author | Fernández Dueñas, Víctor | - |
dc.contributor.author | Watanabe, Masahiko | - |
dc.contributor.author | Adelman, John P. | - |
dc.contributor.author | Shigemoto, Ryuichi | - |
dc.contributor.author | Fukazawa, Yugo | - |
dc.contributor.author | Luján, Rafael | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2017-05-04T12:23:34Z | - |
dc.date.available | 2017-05-04T12:23:34Z | - |
dc.date.issued | 2014-10-29 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/2445/110442 | - |
dc.description.abstract | Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The Society for Neuroscience | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.2038-14.2014 | - |
dc.relation.ispartof | Journal of Neuroscience, 2014, vol. 34, num. 44, p. 14793-14802 | - |
dc.relation.uri | https://doi.org/10.1523/JNEUROSCI.2038-14.2014 | - |
dc.rights | cc-by-nc-sa (c) García-Negredo, Gloria et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Canals de potassi | - |
dc.subject.classification | Neurologia | - |
dc.subject.classification | Hipocamp (Cervell) | - |
dc.subject.classification | Farmacologia | - |
dc.subject.classification | Rates (Animals de laboratori) | - |
dc.subject.other | Potassium channels | - |
dc.subject.other | Neurology | - |
dc.subject.other | Hippocampus (Brain) | - |
dc.subject.other | Pharmacology | - |
dc.subject.other | Rats as laboratory animals | - |
dc.title | Coassembly and coupling of SK2 channels and mGlu5 receptors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643622 | - |
dc.date.updated | 2017-05-04T12:23:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25355231 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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643622.pdf | 2.7 MB | Adobe PDF | View/Open |
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