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Title: Bike peptides: a ride through the membrane
Author: García Pindado, Júlia
Royo, Soledad
Teixidó Turà, Meritxell
Giralt Lledó, Ernest
Keywords: Síntesi de pèptids
Productes naturals
Síntesi orgànica
Peptide synthesis
Natural products
Organic synthesis
Issue Date: 16-Mar-2017
Publisher: John Wiley & Sons
Abstract: Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability
Note: Versió postprint del document publicat a:
It is part of: Journal of Peptide Science, 2017, vol. 23, num. 4, p. 294-302
Related resource:
ISSN: 1075-2617
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

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