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http://hdl.handle.net/2445/110906
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DC Field | Value | Language |
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dc.contributor.author | Serrano-Oviedo, Leticia | - |
dc.contributor.author | Giménez-Bachs, José Miguel | - |
dc.contributor.author | Nam-Cha, Syong Hyun | - |
dc.contributor.author | Cimas, Francisco J. | - |
dc.contributor.author | García-Cano, Jesús | - |
dc.contributor.author | Sánchez-Prieto, Ricardo | - |
dc.contributor.author | Salinas-Sánchez, Antonio S. | - |
dc.date.accessioned | 2017-05-12T08:33:58Z | - |
dc.date.available | 2017-11-08T23:01:27Z | - |
dc.date.issued | 2016-11-08 | - |
dc.identifier.issn | 1078-1439 | - |
dc.identifier.uri | http://hdl.handle.net/2445/110906 | - |
dc.description.abstract | Objectives: To determine the expression status of several proteins related to VHL gene function and its relationship with common clinicopathological parameters. Material and methods: Observational, analytical, cross-sectional study with 50 patients diagnosed with clear cell renal cell carcinoma. The study analyzed VHL mutations and hypermethylation as well as protein expression of VHL, CA-IX, HIF-1alpha, VEGF, ERK1/2, and ERK5, relating them to clinical variables. A bivariate and multivariate descriptive logistical regression analysis was performed, using the presence of metastasis at diagnosis as dependent variable. Results: The study identified 13 (26%) VHL mutations related to nuclear grade (P = 0.036). VHL hypermethylation was found in 20% of cases. VHL expression was associated with the presence of mutations (P = 0.013), and the absence of expression was associated with nuclear grade and the presence of metastasis (P<0.05). HIF-1alpha was negative in only 5 cases. Vascular endothelial growth factor (VEGF) was positive in 31 of 47 cases and was associated with Fuhrman nuclear grade, presence of metastasis, and stage (P<0.05). ERK5 expression was increased in 58% of cases and associated with the presence of metastasis and more advanced stages (P<0.05). In the logistic regression analysis, the only variable remaining in the model was VEGF expression (P = 0.014). Conclusions: VEGF has prognostic value in clear cell renal cell carcinoma, and ERK5 may be a new prognostic marker in this type of tumor owing to its relationship with metastasis and more advanced stages. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.urolonc.2016.10.010 | - |
dc.relation.ispartof | Urologic Oncology-Seminars and Original Investigations, 2017, vol. 35, num. 3, p. 114.e15-114.e22 | - |
dc.relation.uri | https://doi.org/10.1016/j.urolonc.2016.10.010 | - |
dc.rights | cc-by-nc-nd (c) Elsevier Inc. , 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.classification | Càncer de ronyó | - |
dc.subject.classification | Metàstasi | - |
dc.subject.other | Proteins | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Tumor markers | - |
dc.subject.other | Renal cancer | - |
dc.subject.other | Metastasis | - |
dc.title | Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 670347 | - |
dc.date.updated | 2017-05-12T08:33:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
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670347.pdf | 670.71 kB | Adobe PDF | View/Open |
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