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http://hdl.handle.net/2445/110933
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DC Field | Value | Language |
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dc.contributor.author | Galatas, Beatriz | - |
dc.contributor.author | Nhamussua, Lidia | - |
dc.contributor.author | Candrinho, Baltazar | - |
dc.contributor.author | Mabote, Lurdes | - |
dc.contributor.author | Cisteró, Pau | - |
dc.contributor.author | Gupta, Himanshu | - |
dc.contributor.author | Rabinovich, Regina | - |
dc.contributor.author | Menéndez, Clara | - |
dc.contributor.author | Macete, Eusebio Víctor | - |
dc.contributor.author | Saute, Francisco | - |
dc.contributor.author | Mayor Aparicio, Alfredo Gabriel | - |
dc.contributor.author | Alonso, Pedro | - |
dc.contributor.author | Bassat Orellana, Quique | - |
dc.contributor.author | Aide, Pedro Carlos Paulino | - |
dc.date.accessioned | 2017-05-12T11:55:26Z | - |
dc.date.available | 2017-05-12T11:55:26Z | - |
dc.date.issued | 2017-05-02 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/110933 | - |
dc.description.abstract | Recent reports regarding the re-emergence of parasite sensitivity to chloroquine call for a new consideration of this drug as an interesting complementary tool in malaria elimination efforts, given its good safety profile and long half-life. A randomized (2:1), single-blind, placebo-controlled trial was conducted in Manhica, Mozambique, to assess the in-vivo efficacy of chloroquine to clear plasmodium falciparum (Pf) asymptomatic infections. Primary study endpoint was the rate of adequate and parasitological response (ACPR) to therapy on day 28 (PCR-corrected). Day 0 isolates were analyzed to assess the presence of the PfCRT-76T CQ resistance marker. A total of 52 and 27 male adults were included in the CQ and Placebo group respectively. PCR-corrected ACPR was significantly higher in the CQ arm 89.4% (95%CI 80-98%) compared to the placebo (p < 0.001). CQ cleared 49/50 infections within the first 72 h while placebo cleared 12/26 (LRT p < 0.001). The PfCRT-76T mutation was present only in one out of 108 (0.9%) samples at baseline, well below the 84% prevalence found in 1999 in the same area. This study presents preliminary evidence of a return of chloroquine sensitivity in Mozambican Pf isolates, and calls for its further evaluation in community-based malaria elimination efforts, in combination with other effective anti-malarials. TRIAL REGISTRATION: www.clinicalTrials.gov NCT02698748. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/s41598-017-01365-4 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 1, p. 1356 | - |
dc.relation.uri | http://dx.doi.org/10.1038/s41598-017-01365-4 | - |
dc.rights | cc by (c) Galatas et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Moçambic | - |
dc.subject.other | Malaria | - |
dc.subject.other | Mozambique | - |
dc.title | In-Vivo Efficacy of Chloroquine to Clear Asymptomatic Infections in Mozambican Adults: A Randomized, Placebo-controlled Trial with Implications for Elimination Strategies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-05-10T18:00:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28465550 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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galatas2017_2527.pdf | 1.49 MB | Adobe PDF | View/Open |
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