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http://hdl.handle.net/2445/110938
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DC Field | Value | Language |
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dc.contributor.author | Mira Martínez, Sofía | - |
dc.contributor.author | Schuppen, Evi van | - |
dc.contributor.author | Amambua-Ngwa, Alfred | - |
dc.contributor.author | Bottieau, Emmanuel | - |
dc.contributor.author | Affara, Muna | - |
dc.contributor.author | Esbroeck, Marjan van | - |
dc.contributor.author | Vlieghe, Erika | - |
dc.contributor.author | Guetens, Pieter | - |
dc.contributor.author | Rovira Graells, Núria | - |
dc.contributor.author | Gomez-Perez, Gloria P. | - |
dc.contributor.author | Alonso, Pedro | - |
dc.contributor.author | D'Alessandro, Umberto | - |
dc.contributor.author | Rosanas Urgell, Anna | - |
dc.contributor.author | Cortés, Alfred | - |
dc.date.accessioned | 2017-05-12T12:03:35Z | - |
dc.date.available | 2018-02-07T23:01:16Z | - |
dc.date.issued | 2017-02-07 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/2445/110938 | - |
dc.description.abstract | Background.: Many genes of the malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic level. These genes participate in fundamental host-parasite interactions and contribute to adaptive processes. However, little is known about their expression patterns during human infections. A peculiar case of clonally variant genes are the 2 nearly identical clag3 genes, clag3.1 and clag3.2, which mediate nutrient uptake and are linked to resistance to some toxic compounds. Methods.: We developed a procedure to characterize the expression of clag3 genes in naturally infected patients and in experimentally infected human volunteers. Results.: We provide the first description of clag3 expression during human infections, which revealed mutually exclusive expression and identified the gene predominantly expressed. Adaptation to culture conditions or selection with a toxic compound resulted in isolate-dependent changes in clag3 expression. We also found that clag3 expression patterns were reset during transmission stages. Conclusions.: Different environment conditions select for parasites with different clag3 expression patterns, implying functional differences between the proteins encoded. The epigenetic memory is likely erased before parasites start infection of a new human host. Altogether, our findings support the idea that clonally variant genes facilitate the adaptation of parasite populations to changing conditions through bet-hedging strategies. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1093/infdis/jix053 | - |
dc.relation.ispartof | The Journal of Infectious Diseases, 2017, vol. 215, num. 6 , p. 938-945 | - |
dc.relation.uri | http://dx.doi.org/10.1093/infdis/jix053 | - |
dc.rights | (c) Mira-Martinez et al., 2017 | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Plasmodium falciparum | - |
dc.subject.other | Malaria | - |
dc.subject.other | Plasmodium falciparum | - |
dc.title | Expression of the Plasmodium falciparum Clonally Variant clag3 Genes in Human Infections | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2017-05-03T18:01:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28419281 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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mira-martinez2017_2510.pdf | 750.12 kB | Adobe PDF | View/Open |
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