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Title: MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
Author: Barragán, Rocío
Coltell, Oscar
Asensio, Eva M.
Francés, Francesc
Sorlí, José V.
Estruch Riba, Ramon
Salas-Huetos, Albert
Ordovás, José M.
Corella Piquer, Dolores
Keywords: Micro RNAs
Cuina mediterrània
Consum d'alcohol
Genètica molecular
Mediterranean cooking
Drinking of alcoholic beverages
Molecular genetics
Issue Date: 16-Aug-2016
Publisher: MDPI
Abstract: Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 ± 0.4 in AA, 5.9 ± 0.5 in AG and 9.1 ± 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2016, vol. 17, num. 8, p. E1338
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ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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