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http://hdl.handle.net/2445/111024
Title: | Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease |
Author: | Sanchez-Mut, Jose Vicente Aso Pérez, Ester Heyn, Holger Matsuda, Tadashi Bock, Christoph Ferrer, Isidro (Ferrer Abizanda) Esteller, Manel |
Keywords: | Epigènesi Metilació ADN Hipocamp (Cervell) Malaltia d'Alzheimer Malalties neurodegeneratives Epigenesis Methylation DNA Hippocampus (Brain) Alzheimer's disease Neurodegenerative Diseases |
Issue Date: | Apr-2014 |
Publisher: | Wiley |
Abstract: | Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a likely candidate gene for involvement in the pathogenesis of the disorder since, as we demonstrate here, it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/hipo.22245 |
It is part of: | Hippocampus, 2014, vol. 24, num. 4, p. 363-368 |
URI: | http://hdl.handle.net/2445/111024 |
Related resource: | https://doi.org/10.1002/hipo.22245 |
ISSN: | 1050-9631 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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