Please use this identifier to cite or link to this item:
Title: Postnatal anthropometric and body composition profiles in infants with intrauterine growth restriction identified by prenatal doppler
Author: Mazarico Gallego, Edurne
Martinez-Cumplido, R.
Díaz, Marta
Sebastiani, Giorgia
Ibáñez Toda, Lourdes
Gómez Roig, Ma. Dolores
Keywords: Puerperi
Composició corporal
Ecografia Doppler
Retard del creixement intrauterí
Monitoratge fetal
Body composition
Doppler ultrasonography
Fetal growth retardation
Fetal monitoring
Issue Date: Mar-2016
Publisher: Public Library of Science (PLoS)
Abstract: Introduction: Infant anthropometry and body composition have been previously assessed to gauge the impact of intrauterine growth restriction (IUGR) at birth, but the interplay between prenatal Doppler measurements and postnatal development has not been studied in this setting. The present investigation was performed to assess the significance of prenatal Doppler findings relative to postnatal anthropometrics and body composition in IUGR newborns over the first 12 months of life. Patients and methods: Consecutive cases of singleton pregnancies with suspected IUGR were prospectively enrolled over 12 months. Fetal biometry and prenatal Doppler ultrasound examinations were performed. Body composition was assessed by absorptiometry at ages 10 days, and at 4 and12 months. Results: A total of 48 pregnancies qualifying as IUGR were studied. Doppler parameters were normal in 26 pregnancies. The remaining 22 deviated from normal, marked by an Umbilical Artery Pulsatility Index (UA-PI) >95th centil or Cerebro-placental ratio (CPR) <5th centile. No significant differences emerged when comparing anthropometry and body composition at each time point, in relation to Doppler findings. Specifically, those IUGR newborns with and without abnormal Doppler findings had similar weight, length, body mass index, lean and fat mass, and bone mineral content throughout the first 12 months of life. In a separate analysis, when comparing IUGR newborns by Doppler (abnormal UA-PI vs. abnormal CPR), anthropometry and body composition did not differ significantly. Conclusions: Infants with IUGR maintain a pattern of body composition during the first year of life that is independent of prenatal Doppler findings. Future studies with larger sample sizes and correlating with hormonal status are warranted to further extend the phenotypic characterization of the various conditions now classified under the common label of IUGR.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2016, vol. 11, num. 3, p. e0150152
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Files in This Item:
File Description SizeFormat 
659570.pdf196.71 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons