Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/111110
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Azagra Rodríguez, Alba | - |
dc.contributor.author | Román González, Lidia | - |
dc.contributor.author | Collazo, Olga | - |
dc.contributor.author | Rodríguez Ubreva, Javier | - |
dc.contributor.author | Yébenes, Virginia G. de | - |
dc.contributor.author | Barneda Zahonero, Bruna | - |
dc.contributor.author | Rodríguez Lumbiarres, Jairo, 1980- | - |
dc.contributor.author | Castro de Moura, Manuel | - |
dc.contributor.author | Grego Bessa, Joaquim | - |
dc.contributor.author | Fernández Duran, Irene | - |
dc.contributor.author | Islam, Abul B. M. M. K. | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Ramiro, Almudena R. | - |
dc.contributor.author | Ballestar Tarín, Esteban | - |
dc.contributor.author | Parra Bola, Mª Isabel | - |
dc.date.accessioned | 2017-05-16T13:17:50Z | - |
dc.date.available | 2017-05-30T22:01:30Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111110 | - |
dc.description.abstract | Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A prominent example is HDAC7, a class IIa HDAC that shows a lymphoid-specific expression pattern within the hematopoietic system. In this study, we explored its potential role in B cell development by generating a conditional knockout mouse model. Our study demonstrates for the first time that HDAC7 deletion dramatically blocks early B cell development and gives rise to a severe lymphopenia in peripheral organs, while also leading to pro-B cell lineage promiscuity. We find that HDAC7 represses myeloid and T lymphocyte genes in B cell progenitors through interaction with myocyte enhancer factor 2C (MEFC2). In B cell progenitors, HDAC7 is recruited to promoters and enhancers of target genes, and its absence leads to increased enrichment of histone active marks. Our results prove that HDAC7 is a bona fide transcriptional repressor essential for B cell development. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1084/jem.20150821 | - |
dc.relation.ispartof | Journal of Experimental Medicine, 2016, vol. 213, num. 12, p. 2591-2601 | - |
dc.relation.uri | https://doi.org/10.1084/jem.20150821 | - |
dc.rights | (c) Rockefeller University Press, 2016 | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.classification | Histones | - |
dc.subject.classification | Limfòcits | - |
dc.subject.classification | Gens | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | B cells | - |
dc.subject.other | Histones | - |
dc.subject.other | Lymphocytes | - |
dc.subject.other | Genes | - |
dc.subject.other | Proteins | - |
dc.title | In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 669675 | - |
dc.date.updated | 2017-05-16T13:17:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27810920 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
669675.pdf | 2.22 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.