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DC Field | Value | Language |
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dc.contributor.author | Torres, Berta | - |
dc.contributor.author | Guardo, Alberto C. | - |
dc.contributor.author | Leal, Lorna | - |
dc.contributor.author | León García, Agathe | - |
dc.contributor.author | Lucero, Constanza | - |
dc.contributor.author | Álvarez Martínez, Míriam | - |
dc.contributor.author | Martínez Yoldi, Miguel Julián | - |
dc.contributor.author | Vila Estapé, Jordi | - |
dc.contributor.author | Martínez Rebollar, María | - |
dc.contributor.author | González Cordón, Ana | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Plana Prades, Montserrat | - |
dc.contributor.author | García Alcaide, Felipe | - |
dc.date.accessioned | 2017-05-17T09:45:39Z | - |
dc.date.available | 2017-05-17T09:45:39Z | - |
dc.date.issued | 2014-09-29 | - |
dc.identifier.issn | 1758-2652 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111156 | - |
dc.description.abstract | Introduction Monotherapy with protease-inhibitors (MPI) may be an alternative to cART for HIV treatment. We assessed the impact of this strategy on immune activation, bacterial translocation and inflammation. Methods We performed a cross-sectional study comparing patients on successful MPI (n=40) with patients on cART (n=20). Activation, senescence, exhaustion and differentiation stage in CD4+ and CD8+ T lymphocyte subsets, markers of monocyte activation, microbial translocation, inflammation, coagulation and low-level viremia were assessed. Results CD4+ or CD8+ T lymphocyte subset parameters were not significantly different between both groups. Conversely, as compared with triple cART, MPI patients showed a higher proportion of activated monocytes (CD14+ CD16−CD163+ cells, p=0.031), soluble markers of monocyte activation (sCD14 p=0.004, sCD163 p=0.002), microbial translocation (lipopolysaccharide (LPS)-binding protein; LBP p=0.07), inflammation (IL-6 p=0.04) and low-level viremia (p=0.035). In a multivariate model, a higher level of CD14+ CD16−CD163+ cells and sCD14, and presence of very low-level viremia were independently associated with MPI. Monocyte activation was independently associated with markers of inflammation (IL-6, p=0.006), microbial translocation (LBP, p=0.01) and low-level viremia (p=0.01). Conclusions Patients on MPI showed a higher level of monocyte activation than patients on standard therapy. Microbial translocation and low-level viremia were associated with the high level of monocyte activation observed in patients on MPI. The long-term clinical consequences of these findings should be assessed. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.7448/IAS.17.1.19246 | - |
dc.relation.ispartof | Journal of the International AIDS Society, 2014, vol. 17, num. 1, p. 19246 | - |
dc.relation.uri | https://doi.org/10.7448/IAS.17.1.19246 | - |
dc.rights | cc-by (c) Torres, Berta et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Limfòcits | - |
dc.subject.classification | Translocació (Genètica) | - |
dc.subject.classification | Inhibidors enzimàtics | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | Lymphocytes | - |
dc.subject.other | Translocation (Genetics) | - |
dc.subject.other | Enzyme inhibitors | - |
dc.title | Protease inhibitor monotherapy is associated with a higher level of monocyte activation, bacterial translocation and inflammation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643591 | - |
dc.date.updated | 2017-05-17T09:45:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25280865 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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