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Title: Associations between whole peripheral blood fatty acids and DNA methylation in humans
Author: Rocha, Carmen de la
Pérez-Mojica, J. Eduardo
Zenteno-De León, Silvia
Cervantes-Paz, Braulio
Tristán-Flores, Fabiola E.
Rodríguez-Ríos, Dalia
Molina-Torres, Jorge
Ramírez-Chávez, Enrique
Alvarado-Caudillo, Yolanda
Carmona, F. Javier
Esteller, Manel
Hernández-Rivas, Rosaura
Wrobel, Katarzyna
Wrobel, Kazimierz
Zaina, Silvio
Lund, Gertrud
Keywords: Àcids grassos
Lípids en la nutrició
Trastorns del metabolisme dels lípids
Fatty acids
Lipids in human nutrition
Lipid metabolism disorders
Issue Date: 16-May-2016
Publisher: Nature Publishing Group
Abstract: Fatty acids (FA) modify DNA methylation in vitro, but limited information is available on whether corresponding associations exist in vivo and reflect any short-term effect of the diet. Associations between global DNA methylation and FAs were sought in blood from lactating infants (LI; n = 49) and adult males (AMM; n = 12) equally distributed across the three conventional BMI classes. AMM provided multiple samples at 2-hour intervals during 8 hours after either a single Western diet-representative meal (post-prandial samples) or no meal (fasting samples). Lipid/glucose profile, HDAC4 promoter and PDK4 5'UTR methylation were determined in AMM. Multiple regression analysis revealed that global (in LI) and both global and PDK4-specific DNA methylation (in AMM) were positively associated with eicosapentaenoic and arachidonic acid. HDAC4 methylation was inversely associated with arachidonic acid post-prandially in AMM. Global DNA methylation did not show any defined within-day pattern that would suggest a short-term response to the diet. Nonetheless, global DNA methylation was higher in normal weight subjects both post-prandially and in fasting and coincided with higher polyunsaturated relative to monounsaturated and saturated FAs. We show for the first time strong associations of DNA methylation with specific FAs in two human cohorts of distinct age, diet and postnatal development stage.
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It is part of: Scientific Reports, 2016, vol. 6, p. 25867
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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