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http://hdl.handle.net/2445/111244
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DC Field | Value | Language |
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dc.contributor.author | Baena Fustegueras, Juan Antonio | - |
dc.contributor.author | Ferrer, Roser | - |
dc.contributor.author | Lecube, Albert | - |
dc.contributor.author | Ricart i Jané, David | - |
dc.contributor.author | Rossell, Joana | - |
dc.contributor.author | Peinado Onsurbe, Julia | - |
dc.date.accessioned | 2017-05-18T14:30:38Z | - |
dc.date.available | 2017-05-18T14:30:38Z | - |
dc.date.issued | 2017-02-16 | - |
dc.identifier.issn | 2376-0494 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111244 | - |
dc.description.abstract | Background: The impact of bariatric surgery on abnormalities in blood lipids and lipoprotein metabolism during the perioperative period has been poorly studied. Objective: We studied the impact of bariatric surgery on the composition and quantitative properties of lipoproteins and the activity of lipases in the plasma of perioperative morbidly obese patients. Methods: We examined the plasma lipoproteins and lipolytic activities of 34 morbidly obesepatients one month before surgery (OB), pre-anaesthesia (-S), post-anaesthesia ( S), and one day and one month after open Roux-en-Y gastric bypass (RYGB) surgery. Results: Surgical injury induced acute stress, as evidenced by transitory hyperglycaemia and elevated plasma levels of stress hormones. Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of total cholesterol (p < 0.0001), which was mainly due to a decrease in low-density lipoprotein cholesterol (cLDL) and was confirmed with a significant reduction in the plasma levels of LDL (approximately 26% reduction). Significant (p < 0.0001) changes were detected in the plasma levels of high-density lipoprotein cholesterol (cHDL) as well as a significant decrease (approximately 19% reduction) in the plasma levels of HDL. A significant (p < 0.0001) rise was noted in the plasma levels of both Lipoprotein Lipase (LPL) (approximately 2.6-fold increase) and hepatic lipase (HL) (approximately 2.2-fold increase) on the day after surgery, occurring simultaneously with the maximum increase in C-reactive protein (CRP) and a day after the peak values for non-esterified fatty acid (NEFA), adrenocorticotropin hormone (ACTH), cortisol and glucose. Conclusion: The present study reveals unreported quantitative perioperative changes in plasma lipases and lipoproteins and related metabolic determinants that may contribute to the adaptive metabolic response to RYGB-induced stress. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Ommega Publishers | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.15436/2376-0494.17.1333 | - |
dc.relation.ispartof | Journal of Diabetes and Obesity , 2017, vol. 4, num. 2, p. 1-11 | - |
dc.relation.uri | https://doi.org/10.15436/2376-0494.17.1333 | - |
dc.rights | cc-by (c) Baena-Fustegueras, Juan Antonio et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Obesitat mòrbida | - |
dc.subject.classification | Lipoproteïnes | - |
dc.subject.classification | Lipases | - |
dc.subject.other | Morbid obesity | - |
dc.subject.other | Lipoproteins | - |
dc.subject.other | Lipase | - |
dc.title | Rapid perioperative changes in the quantitative properties of plasma lipases and lipoproteins in morbidly obese surgical patients' | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668049 | - |
dc.date.updated | 2017-05-18T14:30:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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668049.pdf | 2.3 MB | Adobe PDF | View/Open |
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